Cytokines and cytokine receptors : physiology and pathological disorders

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Cytokine receptor family | Catalytic receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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INFLAMMATION Part 6: Chemical Mediators: CYTOKINES: Interleukins & Chemokines

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Physiological potential of cytokines and liver damages

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Bosmann, M. Reeh, P. Sensory receptors in mammalian skin in an in vitro preparation.

Zimmermann, K. Phenotyping sensory nerve endings in vitro in the mouse. Taguchi, T. Cutaneous C-fiber nociceptor responses and nociceptive behaviors in aged Sprague-Dawley rats. Download references. We are grateful to Dr. Miyake, T. Yamashita, Mr. Yamamoto, and Mr. Tashima for expert technical assistance. We thank Mr. Ono and Y. Kitayama for assistance with the experiments. All authors reviewed the manuscript. Correspondence to Hiroki Yoshida or Toshiharu Yasaka. Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Reprints and Permissions. By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Advanced search. Skip to main content. Subjects Chronic pain Neuroimmunology Sensory processing. Abstract Numerous studies have shown that pain sensation is affected by various immune molecules, such as cytokines, in tissues comprising the sensory pathway. Introduction Chronic pain is defined as pain that lasts over three months.


Figure 1. Full size image. Figure 2. Figure 3. Figure 4. Figure 5. Behavioural assessments Thermal sensitivity To assess sensitivity to heat, we conducted the hot-plate and tail-flick tests. Mechanical sensitivity To assess mechanical sensitivity, mice were placed individually in a transparent glass cylinder and separated from each other by an opaque divider, which was placed on a wire mesh. Formalin-induced nociceptive behaviours The procedure used for the formalin test has been described elsewhere 54 , 56 , Your Email:. Colleague's Email:.

Separate multiple e-mails with a ;. Thought you might appreciate this item s I saw at Medicine. Send a copy to your email. Some error has occurred while processing your request. Please try after some time. Back to Top Article Outline. TABLE 1. TABLE 2. TABLE 3. TABLE 4. Efficacy of biological therapies in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol ; — Cited Here Gisbert JP, Panes J. Loss of response and requirement of infliximab dose intensification in Crohn's disease: a review.

Individual medicine in inflammatory bowel disease: monitoring bioavailability, pharmacokinetics and immunogenicity of anti-tumour necrosis factor-alpha antibodies.

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    Clin Gastroenterol Hepatol ; — Antibody response to infliximab and its impact on pharmacokinetics can be transient. Individualised therapy is more cost-effective than dose intensification in patients with Crohn's disease who lose response to anti-TNF treatment: a randomised, controlled trial. Gut ; — Individualized therapy is a long-term cost-effective method compared to dose intensification in Crohn's disease patients failing infliximab. Dig Dis Sci ; — PubMed CrossRef. Development of an algorithm incorporating pharmacokinetics of adalimumab in inflammatory bowel diseases.

    Yanai H, lichtenstein L, Assa A, et al. Levels of drug and antidrug antibodies are associated with outcome of interventions after loss of response to infliximab or adalimumab. Implications of infliximab treatment failure and influence of personalized treatment on patient-reported health-related quality of life and productivity outcomes in Crohn's disease. J Crohns Colitis ; — Ben-Horin S, Chowers Y.

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    Nat Rev Gastroenterol Hepatol ; — Impact of antibodies to infliximab on clinical outcomes and serum infliximab levels in patients with inflammatory bowel disease IBD : a meta-analysis. Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease. Gastroenterology ; — Loss of infliximab into feces is associated with lack of response to therapy in patients with severe ulcerative colitis.

    Therapeutic drug monitoring of anti-tumor necrosis factor agents in patients with inflammatory bowel diseases. Inflamm Bowel Dis ; — New insights into the mechanisms of action of anti-tumor necrosis factor-alpha monoclonal antibodies in inflammatory bowel disease. Cut-off levels and diagnostic accuracy of infliximab trough levels and anti-infliximab antibodies in Crohn's disease.

    Changes in serum trough levels of infliximab during treatment intensification but not in anti-infliximab antibody detection are associated with clinical outcomes after therapeutic failure in Crohn's disease.